Fishing for peroxidase protons

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Science  11 Jul 2014:
Vol. 345, Issue 6193, pp. 142-143
DOI: 10.1126/science.1256754

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Cytochrome c peroxidase (CcP) consumes hydrogen peroxide in mitochondria, using electrons derived from reduced cytochrome c. This and a related enzyme, horseradish peroxidase (HRP), have played key roles in the development of structural and mechanistic biochemistry and are used in biocatalysis and chemiluminescent bioassays (1). On page 193 of this issue, Casadei et al. (2) use neutron diffraction to reveal the role and origin of protons in heme oxidation by hydrogen peroxide, a key step in this essential enzymatic reaction.