Research Article

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

See allHide authors and affiliations

Science  15 Aug 2014:
Vol. 345, Issue 6198, 1255903
DOI: 10.1126/science.1255903

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

The nutritional sins of the mother…

Prenatal exposures of a mother can affect the health of her offspring, but how? Radford et al. found that the male progeny of undernourished pregnant mice had altered DNA chemistry in their sperm. In addition, the offspring displayed compromised metabolic health. The specific affected genes not only lost DNA methylation but also lacked the normal sperm DNA packaging factors (protamines) and instead were enriched in nucleosomes. Thus, when subjected to a suboptimal prenatal environment, offspring feel the effects of the maternal assault.

Science, this issue p. 10.1126/science.1255903