Self-assembled RNA nanostructures

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Science  15 Aug 2014:
Vol. 345, Issue 6198, pp. 732-733
DOI: 10.1126/science.1257989

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The aim of nanobiotechnology based on nucleic acids is to make three-dimensional objects with both precise architecture and function that can be programmed via their sequence. The ultimate goal is to build self-assembling, biologically active nanostructures within targeted cells by harnessing the cellular nucleic acid synthesis and assembly machineries. On page 799 of this issue, Geary et al. (1) move us closer to this goal by designing RNA “tiles” that can fold into modular units as they are transcribed.