Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming

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Science  15 Aug 2014:
Vol. 345, Issue 6198, pp. 822-825
DOI: 10.1126/science.1254745

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Factor in oocyte assists reprogramming

Unfertilized eggs contain components that can dedifferentiate other cells that have gone down the path toward a specific cell fate. Gonzalez-Muñoz et al. show that the protein-folding factor ASF1A facilitates this reprogramming event and it acts at a particular phase of germ cell division termed metaphase II. ASF1A helps turn differentiated cells such as human adult dermal fibroblasts into undifferentiated pluripotent stem cells.

Science, this issue p. 822