Adc17 modifies proteasomes levels
ILLUSTRATION: BRYCE SMALL/STANFORD UNIVERSITY
Cells need to clear out damaged proteins, or they age and become unhealthy. To do this, cells use tiny protein-destroying machines called proteasomes. Building these proteasomes is a complex process, and it's not clear how stressed cells can make sure the proteasome supply meets demand. Working with yeast cells, Hanssum et al. discovered a protein that helps cells assemble just enough proteasomes to fit their needs. In a process called chaperoning, the protein, which they called Adc17, helps pair two proteasomal proteins, Rpt6 and Rpt3, during proteasome assembly.
Mol. Cell 10.1016/j.molcel.2014.06.017 (2014).
