Research Article

Transcriptional diversity during lineage commitment of human blood progenitors

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Science  26 Sep 2014:
Vol. 345, Issue 6204, 1251033
DOI: 10.1126/science.1251033

Article Information

vol. 345 no. 6204

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History: 
  • Received for publication January 20, 2014
  • Accepted for publication August 28, 2014
  • .

Author Information

  1. Lu Chen1,2,3,*,
  2. Myrto Kostadima2,4,3,*,
  3. Joost H. A. Martens5,*,
  4. Giovanni Canu2,3,
  5. Sara P. Garcia2,3,
  6. Ernest Turro2,3,
  7. Kate Downes2,3,
  8. Iain C. Macaulay6,
  9. Ewa Bielczyk-Maczynska2,3,
  10. Sophia Coe2,3,
  11. Samantha Farrow2,3,
  12. Pawan Poudel2,3,
  13. Frances Burden2,3,
  14. Sjoert B. G. Jansen2,3,
  15. William J. Astle2,3,7,
  16. Antony Attwood2,3,
  17. Tadbir Bariana8,9,
  18. Bernard de Bono10,11,
  19. Alessandra Breschi12,
  20. John C. Chambers13,14,
  21. BRIDGE Consortium,
  22. Fizzah A. Choudry2,3,
  23. Laura Clarke4,
  24. Paul Coupland1,
  25. Martijn van der Ent5,
  26. Wendy N. Erber15,
  27. Joop H. Jansen16,
  28. Rémi Favier17,
  29. Matthew E. Fenech18,
  30. Nicola Foad2,3,
  31. Kathleen Freson19,
  32. Chris van Geet19,
  33. Keith Gomez9,
  34. Roderic Guigo12,
  35. Daniel Hampshire2,3,
  36. Anne M. Kelly2,3,20,
  37. Hindrik H. D. Kerstens5,
  38. Jaspal S. Kooner13,14,
  39. Michael Laffan21,
  40. Claire Lentaigne21,
  41. Charlotte Labalette2,3,
  42. Tiphaine Martin2,3,22,,
  43. Stuart Meacham2,3,
  44. Andrew Mumford23,
  45. Sylvia T. Nürnberg2,3,§,
  46. Emilio Palumbo12,
  47. Bert A. van der Reijden16,
  48. David Richardson4,
  49. Stephen J. Sammut24,25,
  50. Greg Slodkowicz4,
  51. Asif U. Tamuri4,
  52. Louella Vasquez3,
  53. Katrin Voss2,3,,
  54. Stephen Watt3,
  55. Sarah Westbury26,
  56. Paul Flicek4,1,
  57. Remco Loos4,
  58. Nick Goldman4,
  59. Paul Bertone4,27,28,
  60. Randy J. Read29,
  61. Sylvia Richardson7,
  62. Ana Cvejic2,1,
  63. Nicole Soranzo1,2,*,
  64. Willem H. Ouwehand2,3,1,*,
  65. Hendrik G. Stunnenberg5,*,
  66. Mattia Frontini2,3,*,||,
  67. Augusto Rendon2,3,7,*,||
  1. 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  2. 2Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  3. 3National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  4. 4European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  5. 5Department of Molecular Biology, Radboud University, 6525 GA Nijmegen, Netherlands.
  6. 6Sanger Institute–EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  7. 7Medical Research Council Biostatistics Unit, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK.
  8. 8Department of Haematology, University College London Cancer Institute, London WC1E 6DD, UK.
  9. 9The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free NHS Trust, London NW3 2QG, UK.
  10. 10CHIME Institute, University College London, Archway Campus, London NW1 2DA, UK.
  11. 11Auckland Bioengineering Institute, University of Auckland, Auckland 1010, New Zealand.
  12. 12Centre for Genomic Regulation and University Pompeu Fabra, 08002 Barcelona, Spain.
  13. 13Imperial College Healthcare NHS Trust, DuCane Road, London W12 0HS, UK.
  14. 14Ealing Hospital NHS Trust, Southall, Middlesex UB1 3HW, UK.
  15. 15Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia.
  16. 16Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
  17. 17Assistance Publique–Hopitaux de Paris, INSERM U1009, 94805 Villejuif, France.
  18. 18Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.
  19. 19Center for Molecular and Vascular Biology, University of Leuven, 3000 Leuven, Belgium.
  20. 20Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge B2 0QQ, UK.
  21. 21Department of Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London, London W12 0HS, UK.
  22. 22Department of Twin Research & Genetic Epidemiology, Genetics and Molecular Medicine Division, St Thomas’ Hospital, King’s College, London SE1 7EH, UK.
  23. 23School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK.
  24. 24Department of Oncology, Addenbrooke’s Cambridge University Hospital NHS Trust, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK.
  25. 25Cancer Research UK, Cambridge Institute, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK.
  26. 26School of Clinical Sciences, University of Bristol, Bristol BS2 8DZ, UK.
  27. 27Genome Biology and Developmental Biology Units, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
  28. 28Wellcome Trust—Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK.
  29. 29Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
  1. ||Corresponding author. E-mail: ar506{at}cam.ac.uk (A.R.); mf471{at}cam.ac.uk (M.F.)
  1. * These authors contributed equally to this work.

  • A list of the members of the BRIDGE Bleeding and Platelet Disorders Consortium is available in the supplementary materials.

  • Present address: Department of Twin Research and Genetic Epidemiology, Genetics and Molecular Medicine Division, St Thomas' Hospital, King’s College, London SE1 7EH, UK.

  • § Present address: Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

  • Present address: Loxxess Neuburg GmbH, Augsburger Straße 133, 86633 Neuburg an der Donau, Germany.

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