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Rewriting the genome: Even DNA needs an editor

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Science  03 Oct 2014:
Vol. 346, Issue 6205, pp. 106-108
DOI: 10.1126/science.346.6205.106


Until relatively recently, the power of molecular biology was at once vast and limited. Researchers who wanted to knock out specific genes to see what they did mostly had to restrict such studies to mice, and specific strains at that. Now a new class of genome- and epigenome-editing tools is reshaping the landscape. From Arabidopsis to humans to zebrafish, researchers are finding that, generally speaking, when it comes to the genome, if they can dream it, they can build it.

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