An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

See allHide authors and affiliations

Science  03 Oct 2014:
Vol. 346, Issue 6205, 1248012
DOI: 10.1126/science.1248012

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Controlling stem cells and their niches

Adult organs such as the intestines and skin continually renew themselves every few days or weeks. In several mammalian tissues, this renewal relies on Wnt signaling. Clevers et al. review this crucial role in stem cell self renewal. Wnt plays a pivotal role in tissue regeneration even in the earliest animals. Wnt proteins function mainly as short-range signals between adjacent cells. The short-range, spatially-constrained nature of Wnt signals underpins mammalian stem cell niche architecture and tissue self-organization.

Science, this issue 10.1126/science.1248012

View Full Text

Stay Connected to Science