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HSF-1–mediated cytoskeletal integrity determines thermotolerance and life span

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Science  17 Oct 2014:
Vol. 346, Issue 6207, pp. 360-363
DOI: 10.1126/science.1253168

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Cytoskeleton protects from stress and aging

The transcription factor HSF-1 has an unexpected second function that allows it to extend longevity in worms. Baird et al. expressed a modified form of HSF-1 in nematodes. The modified protein could not activate genes encoding protein chaperones. Such chaperones are thought to protect many cellular proteins from heat shock and other damage during aging However, the modified protein still extended the worm life span by regulating the transcription of other genes. One gene it regulated was pat-10, which encodes a troponin-like calcium binding protein. Overexpression of PAT-10 also extended worm life span, apparently by changing the stability of the actin cytoskeleton.

Science, this issue p. 360