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Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease

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Science  17 Oct 2014:
Vol. 346, Issue 6207, pp. 363-368
DOI: 10.1126/science.1259077

Article Information

vol. 346 no. 6207 363-368

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Print ISSN: 
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History: 
  • Received for publication July 22, 2014
  • Accepted for publication September 16, 2014
  • .

Author Information

  1. Yoshinaga Ito1,
  2. Motomu Hashimoto1,2,3,4,*,
  3. Keiji Hirota2,*,
  4. Naganari Ohkura2,5,
  5. Hiromasa Morikawa2,
  6. Hiroyoshi Nishikawa2,
  7. Atsushi Tanaka2,5,
  8. Moritoshi Furu3,6,
  9. Hiromu Ito3,6,
  10. Takao Fujii3,4,
  11. Takashi Nomura1,
  12. Sayuri Yamazaki7,
  13. Akimichi Morita7,
  14. Dario A. A. Vignali8,9,
  15. John W. Kappler10,11,
  16. Shuichi Matsuda6,
  17. Tsuneyo Mimori4,
  18. Noriko Sakaguchi2,
  19. Shimon Sakaguchi1,2,12,
  1. 1Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
  2. 2Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan.
  3. 3Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
  4. 4Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
  5. 5Department of Frontier Research in Tumor Immunology, Center of Medical Innovation and Translational Research, Osaka University, Osaka 565-0871, Japan.
  6. 6Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
  7. 7Department of Geriatric and Environmental Dermatology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
  8. 8Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
  9. 9Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
  10. 10Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA.
  11. 11Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206, USA.
  12. 12Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan.
  1. Corresponding author. E-mail: shimon{at}ifrec.osaka-u.ac.jp
  1. * These authors contributed equally to this work.

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