A drug fights off ravages of aging in mice

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Science  31 Oct 2014:
Vol. 346, Issue 6209, pp. 597
DOI: 10.1126/science.346.6209.597-e

Interested in a pill to extend life span and delay the onset of age-related diseases? The answer may lie in targeting the enzyme NAD-dependent deactylase sirtuin 1 (SIRT1): Animals with enhanced activity of SIRT1 show some of these effects. To study the effects of long-term SIRT1 activity, Mercken et al. fed mice a synthetic activator of SIRT1 from 6 months of age for the rest of their (∼3-year) life span. The treated mice had 5% and 10% increases in maximum and mean life span, respectively. They also resisted many problems associated with human aging. The mice had more stable blood glucose levels, better muscle endurance and balance, less fat, and suppressed inflammatory responses.

Aging Cell 10.1111/acel.12220 (2014).

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