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A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus

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Science  31 Oct 2014:
Vol. 346, Issue 6209, pp. 641-646
DOI: 10.1126/science.1258705

Article Information

vol. 346 no. 6209 641-646

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History: 
  • Received for publication July 14, 2014
  • Accepted for publication October 2, 2014
  • .

Author Information

  1. Lucy Hepburn1,2,*,
  2. Tomasz K. Prajsnar3,4,5,*,
  3. Catherine Klapholz1,2,
  4. Pablo Moreno1,
  5. Catherine A. Loynes5,6,
  6. Nikolay V. Ogryzko5,
  7. Karen Brown1,2,7,
  8. Mark Schiebler1,2,
  9. Krisztina Hegyi1,2,,
  10. Robin Antrobus1,
  11. Katherine L. Hammond5,6,
  12. John Connolly3,4,
  13. Bernardo Ochoa8,
  14. Clare Bryant9,
  15. Michael Otto10,
  16. Bas Surewaard11,
  17. Suranjith L. Seneviratne12,
  18. Dorothy M. Grogono2,7,
  19. Julien Cachat13,
  20. Tor Ny14,
  21. Arthur Kaser2,
  22. M. Estée Török2,
  23. Sharon J. Peacock2,15,
  24. Matthew Holden15,16,
  25. Tom Blundell8,
  26. Lihui Wang17,
  27. Petros Ligoxygakis17,
  28. Liliana Minichiello18,
  29. C. Geoff Woods1,19,
  30. Simon J. Foster3,4,
  31. Stephen A. Renshaw3,5,6,,
  32. R. Andres Floto1,2,7,
  1. 1Cambridge Institute for Medical Research, University of Cambridge, UK.
  2. 2Department of Medicine, University of Cambridge, UK.
  3. 3Krebs Institute, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.
  4. 4Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.
  5. 5Bateson Centre, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.
  6. 6Department of Infection and Immunity, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.
  7. 7Cambridge Centre for Lung Infection, Papworth Hospital, Cambridge, UK.
  8. 8Department of Biochemistry, University of Cambridge, UK.
  9. 9Department of Veterinary Medicine, University of Cambridge, UK.
  10. 10Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, USA.
  11. 11Department of Medical Microbiology, University Medical Centre, Utrecht, Netherlands.
  12. 12Department of Clinical Immunology, Royal Free Hospital London, UK.
  13. 13Department of Pathology and Immunology, Geneva University, Switzerland.
  14. 14Department of Medical Biochemistry and Biophysics, Umea University, Sweden.
  15. 15Wellcome Trust Sanger Institute, Hinxton, UK.
  16. 16School of Medicine, University of St. Andrews, UK.
  17. 17Biochemistry Department, Oxford University, UK.
  18. 18Pharmacology Department, Oxford University, UK.
  19. 19Department of Medical Genetics, University of Cambridge, UK.
  1. Corresponding author. E-mail: arf27{at}cam.ac.uk (R.A.F.); s.a.renshaw{at}sheffield.ac.uk (S.A.R.)
  1. * These authors contributed equally to this work.

  • Deceased.

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