Science Webinar Series

Improving characterization of monoclonal antibodies: Making a better biotherapeutic

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Science  14 Nov 2014:
Vol. 346, Issue 6211, pp. 868
DOI: 10.1126/science.346.6211.868-c


Characterization of therapeutic proteins remains labor-intensive and time consuming due to their often complex and heterogeneous structure. This has led to a concerted effort within the biotechnology and biopharmaceutical industry to address these bottlenecks as a means to boost the development of more biotherapeutics. Studies in this vein, such as testing the effect of various cell culture conditions on posttranslational modifications or monitoring the purification process of recombinant proteins, produce large numbers of samples that can easily exceed the capacity of modern analytical laboratories. High throughput analytical platforms with high precision, automation, and ease-of-use are therefore in great demand. To this end, the use of microfluidic analytical platforms such as microchip capillary electrophoresis (CE) have greatly increased the efficiency and reproducibility needed for analyzing proteins intended for therapeutic use. In this webinar, our expert panelists will discuss posttranslational modifications and quality assessment of biotherapeutic proteins for biopharmaceutical development using microfluidic-CE characterization.

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