Human Immunology

A (w)holistic approach to track T cells

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Science  21 Nov 2014:
Vol. 346, Issue 6212, pp. 961
DOI: 10.1126/science.346.6212.961-h

Immunologists know a lot about mouse T cells: how they develop, respond to infection, form memory cells, and where they reside. But whether this knowledge h olds true for human T cells is still a black box because of the difficulty in obtaining samples from anywhere other than the blood. To gain more insight into human T cell biology, Thome et al. performed multidimensional, quantitative analyses on T cells obtained from the blood, lymph nodes, spleen, and mucosal tissues of 56 individual organ donors aged 3 to 73 years. They find that the distribution and maintenance of different T cell subsets depends on the differentiation state of the T cell and its location within the body.

Cell 159, 814 (2014).

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