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Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

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Science  28 Nov 2014:
Vol. 346, Issue 6213, pp. 1123-1127
DOI: 10.1126/science.1260044

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Stimulatory signals add up for T cells

T cell activation is a dynamic process. T cells encounter multiple input signals such as antigens, costimulatory molecules, and cytokines at different times and anatomical locations during an infection. But how do T cells integrate this information to determine the extent to which they divide? To find out, Marchingo et al. stimulated mouse T cells in culture with different combinations of inputs and also tracked antigen-specific T cell responses in mice infected with influenza virus. They found that T cells linearly sum the various stimulatory inputs they receive to determine their “division destiny.”

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