Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

See allHide authors and affiliations

Science  28 Nov 2014:
Vol. 346, Issue 6213, pp. 1123-1127
DOI: 10.1126/science.1260044

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Stimulatory signals add up for T cells

T cell activation is a dynamic process. T cells encounter multiple input signals such as antigens, costimulatory molecules, and cytokines at different times and anatomical locations during an infection. But how do T cells integrate this information to determine the extent to which they divide? To find out, Marchingo et al. stimulated mouse T cells in culture with different combinations of inputs and also tracked antigen-specific T cell responses in mice infected with influenza virus. They found that T cells linearly sum the various stimulatory inputs they receive to determine their “division destiny.”

Science, this issue p. 1123

View Full Text

Stay Connected to Science