An inhibitor to expand mouse stem cells

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Science  05 Dec 2014:
Vol. 346, Issue 6214, pp. 1196
DOI: 10.1126/science.346.6214.1196-b

Among their many side effects, treatments such as chemotherapy and radiation deplete stem cells. Therapies to boost their numbers may positively affect patient outcomes. One possible therapeutic target is the protein phosphatase SHIP1. Hematopoietic stem cells expand in mice lacking SHIP1; however, they also develop inflammatory disease. To boost stem cells numbers while hopefully avoiding inflammation, Brooks et al. developed a SHIP1 inhibitor. Adult hematopoietic and mesenchymal stem cell numbers increased in normal mice treated transiently with the inhibitor. The inhibitor also helped mice recover their hematopoietic-lineage cells after radiation treatment.

Stem Cells 10.1002/stem.1902 (2014).

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