Aging in Yeast

DNA circles involved in an aging SAGA

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Science  12 Dec 2014:
Vol. 346, Issue 6215, pp. 1339
DOI: 10.1126/science.346.6215.1339-a

Yeast cells help to reveal the secrets of aging


Budding yeast cells provide a powerful model system to study the mechanisms of aging. As they grow older, yeast cells accumulate extra-chromosomal ribosomal DNA circles, a by-product of DNA repair processes. Somehow, during cell division, these circles are retained in the mother cell where they replicate and limit mother cell viability. Denoth-Lippuner et al. report that the yeast acetyl-transferase complex SAGA plays a role in this process. Cells lacking SAGA are long-lived. SAGA promotes the retention of DNA circles within the nucleus of yeast mother cells by anchoring them to nuclear pores. The nuclear pores and DNA circles accumulate in a sort of cap inside the nuclear envelope, which is preferentially retained in the mother cell.

eLife 3, e03790 (2014).

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