Research Article

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

See allHide authors and affiliations

Science  19 Dec 2014:
Vol. 346, Issue 6216, pp. 1486-1492
DOI: 10.1126/science.346.6216.1486

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

This article has been retracted. Please see:

Endogenous retroviruses trigger B cells

Scattered across our genome are endogenous retroviruses (ERVs), ancient “footprints” of previous viral infections. Scientists do not fully understand their functions, but Zeng et al. now report a role for ERVs in mobilizing a particular type of B cell–driven immune response in mice (T cell–independent, TID), which is usually mounted in response to viral capids or bacterial polysaccharides (see the Perspective by Grasset and Cerutti). Immunizing mice with a model TID antigen elicited an increase in ERV RNA and DNA in the cytoplasm of B cells. Innate immune receptors that recognize cytoplasmic nucleotides then triggered signaling cascades that resulted in the production of immunoglobulin M.

Science, this issue p. 1486; see also p. 1454