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De novo design of a transmembrane Zn2+-transporting four-helix bundle

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Science  19 Dec 2014:
Vol. 346, Issue 6216, pp. 1520-1524
DOI: 10.1126/science.1261172

Article Information

vol. 346 no. 6216 1520-1524

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 12, 2014
  • Accepted for publication November 21, 2014
  • .

Author Information

  1. Nathan H. Joh1,
  2. Tuo Wang2,
  3. Manasi P. Bhate1,
  4. Rudresh Acharya3,
  5. Yibing Wu1,
  6. Michael Grabe1,*,
  7. Mei Hong2,*,
  8. Gevorg Grigoryan4,*,
  9. William F. DeGrado1,*
  1. 1Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
  2. 2Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  3. 3School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, Odisha, India.
  4. 4Department of Computer Science and Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA.
  1. *Corresponding author. E-mail: william.degrado{at}ucsf.edu (W.F.D.); gevorg.grigoryan{at}dartmouth.edu (G.G.); meihong{at}mit.edu (M.H.); michael.grabe{at}ucsf.edu (M.G.)

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