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Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals

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Science  19 Dec 2014:
Vol. 346, Issue 6216, pp. 1536-1540
DOI: 10.1126/science.aaa1292

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For the immune system, silence is golden

For the immune system, balance is key. Immune cells must learn to eliminate invading pathogens but tolerate self. A cell type called regulatory T cells (Tregs) help to maintain this balance, but how they do so, particularly in humans, is unclear. Maeda et al. now report that Tregs “silence” T cells with modest reactivity to self. After culture with Tregs, the silenced T cells proliferated very little and produced almost no cytokines in response to antigen. The authors then examined T cells from healthy donors and from people with an autoimmune disease. Only healthy donors harbored silenced T cells, suggesting that if silencing goes awry, autoimmunity may result.

Science, this issue p. 1536