Research Article
Mechanistic insight from the crystal structure of mitochondrial complex I
- Volker Zickermann1,2,*,†,
- Christophe Wirth3,*,
- Hamid Nasiri4,5,
- Karin Siegmund1,
- Harald Schwalbe2,5,
- Carola Hunte3,†,
- Ulrich Brandt2,6,†
- 1Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe-University, 60438 Frankfurt am Main, Germany.
- 2Cluster of Excellence Frankfurt “Macromolecular Complexes,” Goethe-University, 60438 Frankfurt am Main, Germany.
- 3Institute for Biochemistry and Molecular Biology, ZBMZ, BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
- 4Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
- 5Institute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, 60438 Frankfurt am Main, Germany.
- 6Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
- ↵†Corresponding author. E-mail: zickermann{at}med.uni-frankfurt.de (V.Z.); carola.hunte{at}biochemie.uni-freiburg.de (C.H.); ulrich.brandt{at}radboudumc.nl (U.B.)
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↵* These authors contributed equally to this work.
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Science 02 Jan 2015:
Vol. 347, Issue 6217, pp. 44-49
DOI: 10.1126/science.1259859
