Mechanistic insight from the crystal structure of mitochondrial complex I

Volker Zickermann; Christophe Wirth; Hamid Nasiri; Karin Siegmund; Harald Schwalbe; Carola Hunte; Ulrich Brandt

doi:10.1126/science.1259859

Research Article

Mechanistic insight from the crystal structure of mitochondrial complex I

Volker Zickermann¹,²,*,†,
Christophe Wirth³,*,
Hamid Nasiri⁴,⁵,
Karin Siegmund¹,
Harald Schwalbe²,⁵,
Carola Hunte³,†,
Ulrich Brandt²,⁶,†

¹Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe-University, 60438 Frankfurt am Main, Germany.
²Cluster of Excellence Frankfurt “Macromolecular Complexes,” Goethe-University, 60438 Frankfurt am Main, Germany.
³Institute for Biochemistry and Molecular Biology, ZBMZ, BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
⁴Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
⁵Institute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, 60438 Frankfurt am Main, Germany.
⁶Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

↵†Corresponding author. E-mail: zickermann{at}med.uni-frankfurt.de (V.Z.); carola.hunte{at}biochemie.uni-freiburg.de (C.H.); ulrich.brandt{at}radboudumc.nl (U.B.)

↵* These authors contributed equally to this work.

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Science 02 Jan 2015:
Vol. 347, Issue 6217, pp. 44-49
DOI: 10.1126/science.1259859

Volker Zickermann

1Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe-University, 60438 Frankfurt am Main, Germany.

2Cluster of Excellence Frankfurt “Macromolecular Complexes,” Goethe-University, 60438 Frankfurt am Main, Germany.

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For correspondence: zickermann@med.uni-frankfurt.de carola.hunte@biochemie.uni-freiburg.de ulrich.brandt@radboudumc.nl

Christophe Wirth

3Institute for Biochemistry and Molecular Biology, ZBMZ, BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.

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Hamid Nasiri

4Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

5Institute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, 60438 Frankfurt am Main, Germany.

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Karin Siegmund

1Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe-University, 60438 Frankfurt am Main, Germany.

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Harald Schwalbe

2Cluster of Excellence Frankfurt “Macromolecular Complexes,” Goethe-University, 60438 Frankfurt am Main, Germany.

5Institute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, 60438 Frankfurt am Main, Germany.

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Carola Hunte

3Institute for Biochemistry and Molecular Biology, ZBMZ, BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.

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For correspondence: zickermann@med.uni-frankfurt.de carola.hunte@biochemie.uni-freiburg.de ulrich.brandt@radboudumc.nl

Ulrich Brandt

2Cluster of Excellence Frankfurt “Macromolecular Complexes,” Goethe-University, 60438 Frankfurt am Main, Germany.

6Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

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For correspondence: zickermann@med.uni-frankfurt.de carola.hunte@biochemie.uni-freiburg.de ulrich.brandt@radboudumc.nl

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Mechanistic insight from the crystal structure of mitochondrial complex I

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