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Research Article
Mechanistic insight from the crystal structure of mitochondrial complex I
- Volker Zickermann1,2,*,†,
- Christophe Wirth3,*,
- Hamid Nasiri4,5,
- Karin Siegmund1,
- Harald Schwalbe2,5,
- Carola Hunte3,†,
- Ulrich Brandt2,6,†
- 1Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe-University, 60438 Frankfurt am Main, Germany.
- 2Cluster of Excellence Frankfurt “Macromolecular Complexes,” Goethe-University, 60438 Frankfurt am Main, Germany.
- 3Institute for Biochemistry and Molecular Biology, ZBMZ, BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
- 4Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
- 5Institute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, 60438 Frankfurt am Main, Germany.
- 6Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
- ↵†Corresponding author. E-mail: zickermann{at}med.uni-frankfurt.de (V.Z.); carola.hunte{at}biochemie.uni-freiburg.de (C.H.); ulrich.brandt{at}radboudumc.nl (U.B.)
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↵* These authors contributed equally to this work.
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Science 02 Jan 2015:
Vol. 347, Issue 6217, pp. 44-49
DOI: 10.1126/science.1259859
Vol. 347, Issue 6217, pp. 44-49
DOI: 10.1126/science.1259859
Volker Zickermann
Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe-University, 60438 Frankfurt am Main, Germany.Cluster of Excellence Frankfurt “Macromolecular Complexes,” Goethe-University, 60438 Frankfurt am Main, Germany.
Christophe Wirth
Institute for Biochemistry and Molecular Biology, ZBMZ, BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
Hamid Nasiri
Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.Institute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, 60438 Frankfurt am Main, Germany.
Karin Siegmund
Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe-University, 60438 Frankfurt am Main, Germany.
Harald Schwalbe
Cluster of Excellence Frankfurt “Macromolecular Complexes,” Goethe-University, 60438 Frankfurt am Main, Germany.Institute of Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, 60438 Frankfurt am Main, Germany.
Carola Hunte
Institute for Biochemistry and Molecular Biology, ZBMZ, BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
Ulrich Brandt
Cluster of Excellence Frankfurt “Macromolecular Complexes,” Goethe-University, 60438 Frankfurt am Main, Germany.Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
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