Research Article

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

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Science  02 Jan 2015:
Vol. 347, Issue 6217, pp. 49-53
DOI: 10.1126/science.1259203

Article Information

vol. 347 no. 6217 49-53

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History: 
  • Received for publication July 25, 2014
  • Accepted for publication November 11, 2014
  • .

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Author Information

  1. Alexander Buitrago Santanilla1,
  2. Erik L. Regalado1,
  3. Tony Pereira2,
  4. Michael Shevlin1,
  5. Kevin Bateman2,
  6. Louis-Charles Campeau1,
  7. Jonathan Schneeweis3,
  8. Simon Berritt1,
  9. Zhi-Cai Shi4,
  10. Philippe Nantermet5,
  11. Yong Liu1,
  12. Roy Helmy1,
  13. Christopher J. Welch1,
  14. Petr Vachal6,
  15. Ian W. Davies1,
  16. Tim Cernak7,*,
  17. Spencer D. Dreher1,*
  1. 1Department of Process and Analytical Chemistry, Merck Research Laboratories, Merck and Co. Inc., Rahway, NJ 07065, USA.
  2. 2Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck and Co. Inc., West Point, PA 19486, USA.
  3. 3Department of Pharmacology, Merck Research Laboratories, Merck and Co. Inc., Kenilworth, NJ 07033, USA.
  4. 4Department of Discovery Chemistry, Merck Research Laboratories, Merck and Co. Inc., Kenilworth, NJ 07033, USA.
  5. 5Department of Discovery Chemistry, Merck Research Laboratories, Merck and Co. Inc., West Point, PA 19486, USA.
  6. 6Department of Discovery Chemistry, Merck Research Laboratories, Merck and Co. Inc., Rahway, NJ 07065, USA.
  7. 7Department of Discovery Chemistry, Merck Research Laboratories, Merck and Co. Inc., Boston, MA 02115, USA.
  1. *Corresponding author. E-mail: timothy_cernak{at}merck.com (T.C.); spencer_dreher{at}merck.com (S.D.D.)

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