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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

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Science  02 Jan 2015:
Vol. 347, Issue 6217, pp. 78-81
DOI: 10.1126/science.1260825
  • Fig. 1 The relationship between the number of stem cell divisions in the lifetime of a given tissue and the lifetime risk of cancer in that tissue.

    Values are from table S1, the derivation of which is discussed in the supplementary materials.

  • Fig. 2 Stochastic (replicative) factors versus environmental and inherited factors: R-tumor versus D-tumor classification.

    The adjusted ERS (aERS) is indicated next to the name of each cancer type. R-tumors (green) have negative aERS and appear to be mainly due to stochastic effects associated with DNA replication of the tissues’ stem cells, whereas D-tumors (blue) have positive aERS. Importantly, although the aERS was calculated without any knowledge of the influence of environmental or inherited factors, tumors with high aERS proved to be precisely those known to be associated with these factors. For details of the derivation of aERS, see the supplementary materials.

Additional Files

  • Variation in cancer risk among tissues can be explained by the number of stem cell divisions

    Cristian Tomasetti, Bert Vogelstein

    Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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    • Materials and Methods
    • Fig. S1
    • Table S1
    • References
    Correction (23 January 2015): Fig. S1 has been replaced with a corrected version and the text has been revised to make the terminology consistent with the main text. These changes were requested by the authors at the galley stage but were inadvertently not made by Science.
    The original version is accessible here.

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