For caspases, an escape from death

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Science  09 Jan 2015:
Vol. 347, Issue 6218, pp. 142-143
DOI: 10.1126/science.347.6218.142-b

Caspase proteins are well known for their role in degrading proteins and causing programmed cell death, but researchers now show that they may have nondeadly jobs, too. While looking for proteins that partner with microRNAs (small noncoding RNAs that silence gene expression) to regulate how the nematode Caenorhabditis elegans develops, Weaver et al. found the caspase CED-3. Further experimentation revealed that CED-3 cleaved proteins that play important roles in temporal cell fate patterning, stem cell pluripotency, and microRNA processing.

eLife 10.7554/eLife.04265 (2014).

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