Wound Healing

Wound healing requires senescence

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Science  06 Feb 2015:
Vol. 347, Issue 6222, pp. 624-625
DOI: 10.1126/science.347.6222.624-d

Cells divide as tissues develop and regenerate, but they can only do so a limited number of times. Eventually they stop dividing and enter a state called cellular senescence. Senescent cells secrete a variety of factors, but scientists still do not fully understand the role senescent cells play in many physiological processes, such as wound healing. Demaria et al. now show that wounds close more slowly in mice genetically engineered to lack senescent cells. After wounding, endothelial and mesenchymal cells undergo senescence and secrete the protein PDGF-AA. PDGF-AA helps wounds to heal more quickly by causing myofibroblast cells to differentiate.

Dev. Cell 31, 722 (2014).

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