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Science  06 Feb 2015:
Vol. 347, Issue 6222, pp. 680
DOI: 10.1126/science.347.6222.680-a

Transcriptome Solution

Translational researchers who previously could not obtain global gene expression profiles from biobank samples due to limited amounts of tissue now have access to a wealth of valuable RNA data with the launch of the Ion AmpliSeq Transcriptome Solution for the Ion Proton System. Its ability to draw gene expression profiles from just 10 ng of RNA sets the Ion AmpliSeq Transcriptome Solution apart from other solutions in the market, and it is compatible with formalin-fixed, paraffin-embedded samples. The Ion Ampliseq Solution also provides a faster and more cost-effective workflow without the sample manipulation required for microarrays or analytical complexity normally associated with whole transcriptome RNA-sequencing. The solution is designed with simplicity and flexibility in mind. Differential expression profiles are generated through a push button analysis application within Ion Torrent Suite Software. After primary analysis, current microarray and next generation sequencing users are able to conveniently export data into their existing downstream analysis software app.

Hot Plate Stirrer

The new Analog Hotplate Stirrer with a 7"x7" ceramic coated hot plate has a maximum hot temperature surface rating of 380°with stirring speeds that can be precisely controlled between 100–1,500 rpm at maximum capacity of 5 L. A large control panel includes two easily visible lamps, which indicate when the heating and stirring functions are activated as well as a third lamp to indicate when the unit is powered on. Safety features include an on/off switch conveniently located on the side of the unit, as well as an angled control panel, which extends away from the hot surface. Hotplate stirrers are popular for both biology and chemistry applications, and can be purchased separately as hotplate, magnetic stirrer, or combined hotplate stirrer.

Pipette Tips

BrandTech is introducing the new line of BRAND pipette tips from BRAND GMBH + CO KG, including sterile, nonsterile, filtered, and ultralow retention tips. The line features a new, environmentally-friendly box and insert system with lids that can hinge or lift off. Tips are manufactured in BRAND's new state-of-the-art clean room and packaged DNA-, RNase-, ATP-, and endotoxin-free. Tips fit pipettes from all major manufacturers, including the BRAND Transferpette S.

Luteinizing Hormone ELISA Kit

The new LH ELISA Kit for Sensitive and Rapid Detection of luteinizing hormone (LH) can be used to quantify human LH in serum and plasma samples as well as tissue culture media. This sensitive assay is fully quantitative, with the ability to detect as low as 5.2 mIU/mL of LH, surpassing semi-quantitative Western blot analysis. This assay produces rapid results in less than 2 hours with negligible reactivity to similar glycoprotein hormones. With this new kit, Enzo Life Sciences extends its line of ELISAs for endocrine analysis, including angiotensin I & II, corticosterone, cortisol, DHEA, 17β estradiol, estriol, big endothelin-1, gastrin I, GLP-1, leptin, oxytocin, progesterone, serotonin, substance P, testosterone, Arg8 vasopressin, and 25(OH) vitamin D.

Highly Validated Antibody Conjugates

An exclusive range of highly validated conjugated antibodies is now available for use in key imaging applications including immunofluorescence, flow cytometry, and fluorescent Western blotting. Abcam's conjugated antibodies enable scientists to easily perform multi-protein analysis. It is essential for scientists to study and image proteins in their multi-component state rather than individually, as research findings indicate that proteins rarely operate in isolation but function within multi-protein complexes. The majority of the new antibodies are developed using Abcam's RabMAb technology, and are conjugated to Alexa Fluor dyes, HRP, or biotin, combining high signal to noise ratios with high specificity. Each antibody has been produced and extensively validated by Abcam's scientists. Performance data including images, references and customer reviews is provided with each product.

Gamma-H2AX Assay

A gamma H2AX Pharmacodynamic assay kit for the study of double strand DNA breaks through the detection of gamma H2AX—a phosphorylated histone historically proven to be a highly specific and sensitive molecular marker for double strand DNA damage detection. This new assay has been developed for anticancer drug screening, basic research, and upcoming clinical trials providing one of many tools needed to support hypothesis-driven drug design strategies. Documented variability in DNA double-strand break repair among different segments of the human population may contribute to patient-specific therapeutic toxicities, enabling a more personalized approach to treatment. A quantitative determination of gamma-H2AX levels in response to treatment would help to establish patient-specific dose regimens minimizing the toxicity, while maximizing the efficacy of therapy. The new 96-well nonradioactive enzyme-linked immunosorbent assay documents differences in gamma H2AX levels in peripheral blood mononuclear cells, cultured cells, and tissue biopsies.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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