PerspectiveVirology

Delineating Ebola entry

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Science  27 Feb 2015:
Vol. 347, Issue 6225, pp. 947-948
DOI: 10.1126/science.aaa8121
  1. Ebola's entry.

    A model of infection shows that once the virus is internalized into an endosome, the viral glycoprotein is cleaved and binds to NPC1. The calcium channel TPC2 is then activated prior to a fusion event that releases the viral genome into the cell. The drug tetrandrine blocks TPC2.

    ILLUSTRATION: ADAPTED BY C. BICKEL/SCIENCE