Contents
Vol 347, Issue 6227
Contents
This Week in Science
Editorial
Editors' Choice
Podcasts
- Science Podcast: 13 March Show
On this week's show: Happiness and political persuasion, and a roundup of daily news stories.
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Excitement, anxiety greet LHC restart
Some worry the massive accelerator could produce nothing besides the Higgs boson.
- California fogs are thinning
Warming linked to urbanization prevents low clouds from forming, Los Angeles area study shows.
- Militants leave trail of destruction at Iraqi sites
The Islamic State group strikes one valuable archaeological site after another, destroying priceless ruins and artifacts.
- Can sound open the brain for therapies?
Ultrasound methods breach blood-brain barrier.
- Bird flu virus's promiscuity raises red flags
Novel variants of H7N9 and other strains are arising at alarming rate.
- As Ebola fades, a new threat
With health services devastated in the wake of Ebola, experts are bracing for a deadly measles outbreak in West Africa.
Feature
- The synthesis machine
An automatic device that makes small organic molecules could revolutionize drug discovery.
- Second sight
Eye transplants are science fiction. A team of researchers wants to change that.
Working Life
Letters
Books et al.
- Pick your poison
How getting rid of DDT opened the door for more dangerous pesticides
- Precious metals
Balancing the growing demand for rare earth minerals with sustainable mining practices
Policy Forum
- Get the science right when paying for nature's services
Few projects adequately address design and evaluation
Perspectives
- Toward substitution with no regrets
Advances in chemical design are needed to create safe alternatives to harmful chemicals
- A walk across a quantum lattice
A simple two-atom system is used to probe complex quantum phenomena
- Getting sepsis therapy right
Is decreasing inflammation or increasing the host immune response the better approach?
- Catalysis by nickel in its high oxidation state
A NiIV catalyst couples carbon atoms to oxygen, sulfur, and nitrogen atoms
- How climate influences sea-floor topography
Sea-floor hills show the same periodicity as glacial cycles
Research Article
- Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Diverse innate immune receptors use a common signaling mechanism to activate type I interferons.
Review
Reports
- Design, synthesis, and carbon-heteroatom coupling reactions of organometallic nickel(IV) complexes
Careful tuning of ligands and oxidants accesses high–oxidation-state nickel complexes that could prove useful in catalysis.
- Synthesis of many different types of organic small molecules using one automated process
A protocol for coupling and purifying boronate-substituted building blocks produces a structurally diverse range of compounds.
- A young multilayered terrane of the northern Mare Imbrium revealed by Chang’E-3 mission
In situ ground-penetrating radar measurements of the lunar crust reveal multiple layers of regolith and lava flows.
- Strongly correlated quantum walks in optical lattices
A quantum microscope is used to study the dynamics of two interacting 87Rb atoms performing a quantum walk.
- Coulomb crystallization of highly charged ions
Cold singly charged ions can be used to cool down and confine ions with charges of +13 for precise study of their properties.
- Glacial cycles drive variations in the production of oceanic crust
Spectral analysis reveals topographic variations consistent with glacial cycles across the Australian-Antarctic ocean ridge.
- Reduced vaccination and the risk of measles and other childhood infections post-Ebola
Ebola is terrible, but childhood vaccination needs to resume in West Africa to prevent more deaths from common infections.
- Conservatives report, but liberals display, greater happiness
They don’t say so, but politically more liberal people display more happiness than conservatives via their written words and genuine smiles.
- Direct evidence for human reliance on rainforest resources in late Pleistocene Sri Lanka
Sri Lankan prehistoric human foragers relied primarily on rainforest resources from at least ~20,000 years ago.
- Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway
A G protein signaling regulator and its hypertension-associated mutants are short-lived physiological substrates of the Teb4 ubiquitin ligase.
- Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats
A modified version of a mitochondrial uncoupling agent can ameliorate fatty liver disease in rats, without apparent toxicity.
- K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
Crystal structures clarify how a two-pore potassium channel is regulated by diverse stimuli.
- Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis
The cytokine interleukin-3 drives sepsis in mice and is associated with worse prognosis in septic patients.
- Time-restricted feeding attenuates age-related cardiac decline in Drosophila
Restricting feeding to daytime has health benefits for fruitflies.
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