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A prudent path forward for genomic engineering and germline gene modification

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Science  03 Apr 2015:
Vol. 348, Issue 6230, pp. 36-38
DOI: 10.1126/science.aab1028

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vol. 348 no. 6230 36-38

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  1. David Baltimore1,
  2. Paul Berg2,
  3. Michael Botchan3,4,
  4. Dana Carroll5,
  5. R. Alta Charo6,
  6. George Church7,
  7. Jacob E. Corn4,
  8. George Q. Daley8,9,
  9. Jennifer A. Doudna4,10,*,
  10. Marsha Fenner4,
  11. Henry T. Greely11,
  12. Martin Jinek12,
  13. G. Steven Martin13,
  14. Edward Penhoet14,
  15. Jennifer Puck15,
  16. Samuel H. Sternberg16,
  17. Jonathan S. Weissman4,17,
  18. Keith R. Yamamoto4,18
  1. 1California Institute of Technology, Mail Code 147-75, Pasadena, CA 91125, USA.
  2. 2Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305, USA.
  3. 3University of California, Berkeley, 450 Li Ka Shing no. 3370, Berkeley, CA 94720-3370, USA.
  4. 4Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA.
  5. 5Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Room 4100, Salt Lake City, UT 84112-5650, USA.
  6. 6Department of Medical History and Bioethics, School of Medicine and Public Health, University of Wisconsin Law School, 975 Bascom Mall, Madison, WI 53706, USA.
  7. 7Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
  8. 8Boston Children's Hospital, 300 Longwood Avenue, Karp Family Building, 7th Floor, Boston, MA 02115, USA.
  9. 9Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA.
  10. 10Departments of Molecular and Cell Biology and Chemistry, Howard Hughes Medical Institute, 731 Stanley Hall, MS 3220, University of California, Berkeley, Berkeley, CA 94720-3220, USA.
  11. 11Center for Law and the Biosciences, Crown Quadrangle 559 Nathan Abbott Way Stanford, CA 94305-8610, USA.
  12. 12Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
  13. 13Department of Molecular and Cell Biology, College of Letters and Science, University of California, Berkeley, 210K Durant Hall, Berkeley, CA 94720-2920, USA.
  14. 14Alta Partners, One Embarcadero Center, 37th Floor, San Francisco, CA 94111, USA.
  15. 15Department of Pediatrics UCSF School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
  16. 16Department of Chemistry, 731 Stanley Hall, MS 3220, University of California, Berkeley, CA 94720-3220, USA.
  17. 17Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, Byers Hall, 1700 4th Street, San Francisco, CA 94158-2330, USA.
  18. 18UCSF School of Medicine, 600 16th Street, San Francisco, CA 94158, USA.
  1. *E-mail: doudna{at}berkeley.edu

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