Contents
Vol 348, Issue 6231
Contents
This Week in Science
Editorial
Editors' Choice
Podcasts
- Science Podcast: 10 April Show
On this week's show: Mountain gorilla genomes, and a roundup of daily news stories.
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Iran deal would transform its nuclear infrastructure
Secretive Fordow facility could become a stable isotope factory and international accelerator center.
- Acid oceans cited in Earth's worst die-off
Signature of acidification found in Permian extinctions 250 million years ago.
- U.S. agencies fall in line on public access
Major research funders move to make papers free to all.
- Bully for Brontosaurus!
A comprehensive study of one branch of the dinosaur family tree resurrects Brontosaurus as a valid genus.
- Brazil roils waters with moves to protect aquatic life
Fishing moratorium draws fire from industry and scientists.
- Infectious cancer found in clams
A single leukemia afflicts shellfish beds across hundreds of kilometers, puzzling biologists.
Feature
- Startup liftoff
How flocks of small, cheap satellites, hatched in Silicon Valley, will constantly monitor a changing Earth.
Working Life
Letters
Books et al.
- Cyber crime 2.0
In a world where everything is connected, how will we balance security and privacy?
Policy Forum
- Transatlantic lessons in regulation of mitochondrial replacement therapy
The UK has approved MRT for clinical use, but the discussion has just begun in the U.S.
Perspectives
- Aneuploidy and mother's genes
A human genetic variant found at high frequency is associated with reduced fertility
- Finding nascent proteins the right home
A protein complex prevents promiscuous targeting of nascent polypeptides in the cell
- Details of destruction, one molecule at a time
Protein ubiquitination and destruction by the proteasome is examined at the single-molecule level
- Assembling a complex quantum ensemble
A cold-atom technique is used to identify hidden constraints in thermodynamic ensembles
- An early start for the Panama land bridge
The land bridge between North and South America formed 10 million years earlier than previously thought
- Are trade secrets delaying biosimilars?
Regulations for approving biologic drugs thwart the market for would-be competitors
- A chaotic approach clears up imaging
A laser that emits bright, incoherent light provides an ideal light source for imaging
Research Articles
- Specificity of the anaphase-promoting complex: A single-molecule study
The basis of an important enzyme-target recognition strategy is revealed at the single-molecule level.
- Substrate degradation by the proteasome: A single-molecule kinetic analysis
How added ubiquitin chains regulate protein degradation at the proteasome is shown.
- The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum
The ribosome-binding complex NAC helps membrane and secretory proteins find their correct home in Caenorhabditis elegans.
Reports
- Experimental observation of a generalized Gibbs ensemble
Interferometry suggests that as many as 10 parameters are needed to describe the steady state of an integrable system.
- Mass spectrometry imaging with laser-induced postionization
The sensitivity of mass spectrometric imaging of membrane lipids is boosted by laser-induced gas-phase ionization.
- Quantum versus classical annealing of Ising spin glasses
For quantum machines to have a competitive advantage, they have to be posed the right question.
- Strong water isotopic anomalies in the martian atmosphere: Probing current and ancient reservoirs
Maps of atmospheric water distribution reveal seasonal and spatial variations in the enrichment of deuterium to hydrogen.
- Eddy-driven subduction exports particulate organic carbon from the spring bloom
Ocean eddies can transport appreciable quantities of organic carbon from the surface to depth.
- Middle Miocene closure of the Central American Seaway
The ocean gateway that once separated South America from North America disappeared longer ago than was thought.
- Ocean acidification and the Permo-Triassic mass extinction
A rapid injection of massive amounts of carbon into the atmosphere acidified the oceans, causing mass extinction.
- Molecular nitrogen in comet 67P/Churyumov-Gerasimenko indicates a low formation temperature
Direct measurements of N2 by instruments aboard the Rosetta spacecraft provide clues about the comet’s long history.
- Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos
Prenatal genetic screening reveals the candidate gene Polo-like kinase 4, variants of which may affect embryo survival rates.
- Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
Sephin1 selectively inhibits a protein phosphatase to prevent two protein misfolding diseases in mice.
- Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding
Inbreeding in mountain gorillas increases the threat from disease and environmental change but has purged deleterious mutations.
Erratum
From the AAAS Office of Publishing and Member Services
