An Ebola whole-virus vaccine is protective in nonhuman primates

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Science  24 Apr 2015:
Vol. 348, Issue 6233, pp. 439-442
DOI: 10.1126/science.aaa4919

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Ebola virus vaccine candidate

As there are so few possibilities for drugs and vaccines that protect against the Ebola virus (EBOV), we need more options. Marzi et al. present initial studies in monkeys of a promising whole Ebola virus vaccine based on a defective form of the virus in which an essential viral gene (VP30) is knocked out. One or two doses of this defective virus, with or without further peroxide inactivation, protected against a lethal challenge of EBOV. In limited immunological analyses, protection correlated with the production of antibodies to the EBOV envelope.

Science, this issue p. 439