Research Article

The protein LEM promotes CD8+ T cell immunity through effects on mitochondrial respiration

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Science  29 May 2015:
Vol. 348, Issue 6238, pp. 995-1001
DOI: 10.1126/science.aaa7516

Article Information

vol. 348 no. 6238 995-1001

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History: 
  • Received for publication January 23, 2015
  • Accepted for publication April 6, 2015
  • .

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Author Information

  1. Isobel Okoye1,*,
  2. Lihui Wang1,*,
  3. Katharina Pallmer2,,
  4. Kirsten Richter2,,
  5. Takahuru Ichimura3,
  6. Robert Haas4,
  7. Josh Crouse2,
  8. Onjee Choi1,
  9. Dean Heathcote1,
  10. Elena Lovo1,
  11. Claudio Mauro4,
  12. Reza Abdi3,
  13. Annette Oxenius2,
  14. Sophie Rutschmann1,,
  15. Philip G. Ashton-Rickardt1,3,§
  1. 1Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
  2. 2Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
  3. 3Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA.
  4. 4William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
  1. §Corresponding author. E-mail: p.ashton-rickardt{at}imperial.ac.uk
  1. * These authors contributed equally to this work.

  • These authors contributed equally to this work.

  • Present address: Section of Molecular Immunology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.

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