Research Article
The protein LEM promotes CD8+ T cell immunity through effects on mitochondrial respiration
- Isobel Okoye1,*,
- Lihui Wang1,*,
- Katharina Pallmer2,†,
- Kirsten Richter2,†,
- Takahuru Ichimura3,
- Robert Haas4,
- Josh Crouse2,
- Onjee Choi1,
- Dean Heathcote1,
- Elena Lovo1,
- Claudio Mauro4,
- Reza Abdi3,
- Annette Oxenius2,
- Sophie Rutschmann1,‡,
- Philip G. Ashton-Rickardt1,3,§
- 1Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
- 2Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
- 3Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA.
- 4William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
- ↵§Corresponding author. E-mail: p.ashton-rickardt{at}imperial.ac.uk
↵* These authors contributed equally to this work.
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Science 29 May 2015:
Vol. 348, Issue 6238, pp. 995-1001
DOI: 10.1126/science.aaa7516
Vol. 348, Issue 6238, pp. 995-1001
DOI: 10.1126/science.aaa7516
Isobel Okoye
1Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Lihui Wang
1Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Katharina Pallmer
2Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
Kirsten Richter
2Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
Takahuru Ichimura
3Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA.
Robert Haas
4William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Josh Crouse
2Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
Onjee Choi
1Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Dean Heathcote
1Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Elena Lovo
1Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Claudio Mauro
4William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Reza Abdi
3Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA.
Annette Oxenius
2Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
Sophie Rutschmann
1Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Philip G. Ashton-Rickardt
1Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
3Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA.
