Research Article
The protein LEM promotes CD8+ T cell immunity through effects on mitochondrial respiration
- Isobel Okoye1,*,
- Lihui Wang1,*,
- Katharina Pallmer2,†,
- Kirsten Richter2,†,
- Takahuru Ichimura3,
- Robert Haas4,
- Josh Crouse2,
- Onjee Choi1,
- Dean Heathcote1,
- Elena Lovo1,
- Claudio Mauro4,
- Reza Abdi3,
- Annette Oxenius2,
- Sophie Rutschmann1,‡,
- Philip G. Ashton-Rickardt1,3,§
- 1Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
- 2Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
- 3Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA.
- 4William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
- ↵§Corresponding author. E-mail: p.ashton-rickardt{at}imperial.ac.uk
↵* These authors contributed equally to this work.
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Science 29 May 2015:
Vol. 348, Issue 6238, pp. 995-1001
DOI: 10.1126/science.aaa7516
Vol. 348, Issue 6238, pp. 995-1001
DOI: 10.1126/science.aaa7516
Isobel Okoye
Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Lihui Wang
Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Katharina Pallmer
Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
Kirsten Richter
Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
Takahuru Ichimura
Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA.
Robert Haas
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Josh Crouse
Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
Onjee Choi
Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Dean Heathcote
Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Elena Lovo
Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Claudio Mauro
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Reza Abdi
Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA.
Annette Oxenius
Institute of Microbiology, Eidgenössische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland.
Sophie Rutschmann
Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Philip G. Ashton-Rickardt
Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA.
