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A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

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Science  05 Jun 2015:
Vol. 348, Issue 6239, pp. 1160-1163
DOI: 10.1126/science.aaa1356

Article Information

vol. 348 no. 6239 1160-1163

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History: 
  • Received for publication October 22, 2014
  • Accepted for publication April 15, 2015
  • .

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Author Information

  1. Weiqi Zhang1,*,
  2. Jingyi Li2,*,
  3. Keiichiro Suzuki3,*,
  4. Jing Qu4,*,
  5. Ping Wang1,
  6. Junzhi Zhou1,
  7. Xiaomeng Liu2,
  8. Ruotong Ren1,
  9. Xiuling Xu1,
  10. Alejandro Ocampo3,
  11. Tingting Yuan1,
  12. Jiping Yang1,
  13. Ying Li1,
  14. Liang Shi5,
  15. Dee Guan1,
  16. Huize Pan1,
  17. Shunlei Duan1,
  18. Zhichao Ding1,
  19. Mo Li3,
  20. Fei Yi6,
  21. Ruijun Bai4,
  22. Yayu Wang5,
  23. Chang Chen1,
  24. Fuquan Yang1,
  25. Xiaoyu Li7,
  26. Zimei Wang8,
  27. Emi Aizawa3,
  28. April Goebl3,9,
  29. Rupa Devi Soligalla3,
  30. Pradeep Reddy3,
  31. Concepcion Rodriguez Esteban3,
  32. Fuchou Tang2,10,11,12,,
  33. Guang-Hui Liu1,8,11,13,,
  34. Juan Carlos Izpisua Belmonte3,
  1. 1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  2. 2Biodynamic Optical Imaging Center, College of Life Sciences, Peking University, Beijing 100871, China.
  3. 3Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
  4. 4State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
  5. 5Diagnosis and Treatment Center for Oral Disease, the 306th Hospital of the PLA, Beijing, China.
  6. 6Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  7. 7College of Life Sciences, Peking University, Beijing 100871, China.
  8. 8The Center for Anti-aging and Regenerative Medicine, Shenzhen University, Shenzhen 518060, China.
  9. 9Universidad Católica San Antonio de Murcia, Campus de los Jerónimos s/n, 30107 Guadalupe, Murcia, Spain.
  10. 10Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 100871, China.
  11. 11Center for Molecular and Translational Medicine (CMTM), Beijing 100101, China.
  12. 12Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
  13. 13Beijing Institute for Brain Disorders, Beijing 100069, China.
  1. Corresponding author. E-mail: ghliu{at}ibp.ac.cn (G.-H.L.); tangfuchou{at}pku.edu.cn (F.T.); belmonte{at}salk.edu (J.C.I.B.)
  1. * These authors contributed equally to this work.

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