Research Article
Comprehensive serological profiling of human populations using a synthetic human virome
- George J. Xu1,2,3,4,*,
- Tomasz Kula3,4,5,*,
- Qikai Xu3,4,
- Mamie Z. Li3,4,
- Suzanne D. Vernon6,
- Thumbi Ndung’u7,8,9,10,
- Kiat Ruxrungtham11,
- Jorge Sanchez12,
- Christian Brander13,
- Raymond T. Chung14,
- Kevin C. O’Connor15,
- Bruce Walker8,9,
- H. Benjamin Larman16,
- Stephen J. Elledge3,4,6,†
- 1Program in Biophysics, Harvard University, Cambridge, MA 02115, USA.
- 2Harvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, Cambridge, MA 02139, USA.
- 3Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
- 4Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.
- 5Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA 02115, USA.
- 6Solve ME/CFS Initiative, Los Angeles, CA 90036, USA.
- 7KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
- 8HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, Durban, South Africa.
- 9Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University, Cambridge, MA 02139, USA.
- 10Max Planck Institute for Infection Biology, Chariteplatz, D-10117 Berlin, Germany.
- 11Vaccine and Cellular Immunology Laboratory, Department of Medicine, Faculty of Medicine; and Chula-Vaccine Research Center, Chulalongkorn University, Bangkok, Thailand.
- 12Asociación Civil IMPACTA Salud y Educación, Lima, Peru.
- 13AIDS Research Institute-IrsiCaixa and AIDS Unit, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
- 14Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
- 15Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA.
- 16Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
- ↵†Corresponding author. E-mail: selledge{at}genetics.med.harvard.edu
↵* These authors contributed equally to this work.
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Science 05 Jun 2015:
Vol. 348, Issue 6239, aaa0698
DOI: 10.1126/science.aaa0698
Vol. 348, Issue 6239, aaa0698
DOI: 10.1126/science.aaa0698
George J. Xu
Program in Biophysics, Harvard University, Cambridge, MA 02115, USA.Harvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, Cambridge, MA 02139, USA.Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.
Tomasz Kula
Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA 02115, USA.
Qikai Xu
Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.
Mamie Z. Li
Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.
Suzanne D. Vernon
Solve ME/CFS Initiative, Los Angeles, CA 90036, USA.
Thumbi Ndung’u
KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, Durban, South Africa.Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University, Cambridge, MA 02139, USA.Max Planck Institute for Infection Biology, Chariteplatz, D-10117 Berlin, Germany.
Kiat Ruxrungtham
Vaccine and Cellular Immunology Laboratory, Department of Medicine, Faculty of Medicine; and Chula-Vaccine Research Center, Chulalongkorn University, Bangkok, Thailand.
Jorge Sanchez
Asociación Civil IMPACTA Salud y Educación, Lima, Peru.
Christian Brander
AIDS Research Institute-IrsiCaixa and AIDS Unit, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Raymond T. Chung
Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
Kevin C. O’Connor
Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA.
Bruce Walker
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, Durban, South Africa.Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University, Cambridge, MA 02139, USA.
H. Benjamin Larman
Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Stephen J. Elledge
Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.Solve ME/CFS Initiative, Los Angeles, CA 90036, USA.
