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Cortical folding scales universally with surface area and thickness, not number of neurons

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Science  03 Jul 2015:
Vol. 349, Issue 6243, pp. 74-77
DOI: 10.1126/science.aaa9101

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The best way to fold a mammalian brain

As mammalian brains grew larger through evolution, the organization and folding of brains changed too. In a series of statistical analyses comparing a large number of mammalian species, Mota and Herculano-Houzel found that brain folding is not simply a phylogenetic consequence of brain mass increase (see the Perspective by Striedter and Srinivasan). The exposed surface of the cortex scales across all mammals and across individuals as a single power law of the product of total cortical surface and the square root of cortical thickness.

Science, this issue p. 74; see also p. 31

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