Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

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Science  03 Jul 2015:
Vol. 349, Issue 6243, pp. 88-91
DOI: 10.1126/science.aaa8651

An antibody to lock dengue virus out

Mosquito-borne dengue virus (DENV) is a growing public health threat. Nearly 400 million people are infected annually, and no vaccine is currently available. Fibriansah et al. report that a human antibody (2D22) specific for DENV serotype 2, when given therapeutically, can protect mice from a lethal form of this virus. Structural analysis revealed that 2D22 binds across multiple DENV envelope proteins, which probably blocks the ability of these proteins to assemble into the orientation necessary for viral entry. The epitope where 2D22 binds to the virus may therefore represent a potential vaccine target.

Science, this issue p. 88

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