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Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

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Science  03 Jul 2015:
Vol. 349, Issue 6243, pp. 88-91
DOI: 10.1126/science.aaa8651

Article Information

vol. 349 no. 6243 88-91

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Print ISSN: 
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History: 
  • Received for publication February 6, 2015
  • Accepted for publication May 27, 2015
  • .

Author Information

  1. Guntur Fibriansah1,2,
  2. Kristie D. Ibarra3,
  3. Thiam-Seng Ng1,2,
  4. Scott A. Smith4,5,
  5. Joanne L. Tan1,2,
  6. Xin-Ni Lim1,2,
  7. Justin S. G. Ooi1,2,
  8. Victor A. Kostyuchenko1,2,
  9. Jiaqi Wang1,2,
  10. Aravinda M. de Silva6,
  11. Eva Harris3,
  12. James E. Crowe Jr.5,7,*,
  13. Shee-Mei Lok1,2,*
  1. 1Program in Emerging Infectious Diseases, Duke–National University of Singapore Graduate Medical School, Singapore.
  2. 2Centre for BioImaging Sciences, National University of Singapore, Singapore.
  3. 3Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, USA.
  4. 4Department of Medicine, Vanderbilt University, Nashville, TN, USA.
  5. 5The Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN, USA.
  6. 6Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  7. 7Departments of Pediatrics and Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA.
  1. *Corresponding author. E-mail:
    sheemei.lok{at}duke-nus.edu.sg (S.-M.L.);
    james.crowe{at}vanderbilt.edu (J.E.C.)

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