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Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels

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Science  10 Jul 2015:
Vol. 349, Issue 6244, pp. 187-191
DOI: 10.1126/science.aab1091

Article Information

vol. 349 no. 6244 187-191

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Print ISSN: 
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History: 
  • Received for publication March 12, 2015
  • Accepted for publication June 5, 2015
  • .

Author Information

  1. Ruobing Ren1,2,3,*,
  2. Xinhui Zhou1,2,3,*,
  3. Yuan He1,2,3,
  4. Meng Ke1,2,3,
  5. Jianping Wu1,2,3,
  6. Xiaohui Liu4,
  7. Chuangye Yan1,2,3,
  8. Yixuan Wu1,2,3,
  9. Xin Gong1,2,3,
  10. Xiaoguang Lei4,
  11. S. Frank Yan5,
  12. Arun Radhakrishnan6,
  13. Nieng Yan1,2,3,
  1. 1State Key Laboratory of Membrane Biology, Tsinghua University, Beijing 100084, China.
  2. 2Center for Structural Biology, School of Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
  3. 3Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.
  4. 4National Institute of Biological Sciences, Beijing 102206, China.
  5. 5Molecular Design and Chemical Biology, Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Shanghai, Shanghai 201203, China.
  6. 6Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.
  1. Corresponding author. E-mail: nyan{at}tsinghua.edu.cn
  1. * These authors contributed equally to this work.

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