25 September 2015
Vol 349, Issue 6255

About The Cover

Cover image expansion

COVER Results of an early next-generation DNA sequencing run show four superimposed false-color images of amplified DNA clusters from one of the hundreds of "tiles" contained on a glass flow cell. Recent advances in this increasingly popular and inexpensive method now enable parallel sequencing reactions that can produce up to 500 gigabases of data per instrument run. These data allow us to better understand the frequency of genetic mutations and their impact on human disease. See page 1470 .
Image: Jamie Simon, Ryan Lister, and Joseph R. Ecker, The Salk Institute