From transient infection to chronic disease

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Science  09 Oct 2015:
Vol. 350, Issue 6257, pp. 161
DOI: 10.1126/science.aad4141

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An infection is considered to be resolved when the causative microbe has been cleared and host structure and function return to normal—except, perhaps, for a scar in the affected tissue. In a recent study, da Fonseca et al. (1) argue that some resolved infections leave scars of another sort—longlasting immune dysfunction. The authors propose that “immunologic scarring” by resolved infections may account for a wide range of chronic diseases.