Aging gracefully, one organ at a time

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Science  09 Oct 2015:
Vol. 350, Issue 6257, pp. 174-175
DOI: 10.1126/science.350.6257.174-f

Protein abundance and cellular location change as rats age


You're as old as you feel, goes the old adage, but what is aging at the cellular level? On et al. performed a proteomic and transcriptomic analysis of the brains and livers of 6-month-old young rats and 2-year-old rats. More than 400 proteins changed in abundance between young and old animals, and more than 100 other proteins changed their cellular location, phosphorylation state, or splice form. Although some proteins and protein complexes were altered with age at similar rates, most changes were specific to one organ. These differences could be because of the very different life histories and functions of the two organs: Liver cells continually turn over and regenerate, whereas the brain mostly contains terminally differentiated postmitotic cells.

Cell Syst. 10.1016/j.cels.2015.08.012 (2015).

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