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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

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Science  09 Oct 2015:
Vol. 350, Issue 6257, pp. 207-211
DOI: 10.1126/science.aad0095

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vol. 350 no. 6257 207-211

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History: 
  • Received for publication July 13, 2015
  • Accepted for publication August 27, 2015
  • .

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Author Information

  1. Eliezer M. Van Allen1,2,3,*,
  2. Diana Miao1,2,*,
  3. Bastian Schilling4,5,*,
  4. Sachet A. Shukla1,2,
  5. Christian Blank6,
  6. Lisa Zimmer4,5,
  7. Antje Sucker4,5,
  8. Uwe Hillen4,5,
  9. Marnix H. Geukes Foppen6,
  10. Simone M. Goldinger7,
  11. Jochen Utikal5,8,9,
  12. Jessica C. Hassel10,
  13. Benjamin Weide11,
  14. Katharina C. Kaehler12,
  15. Carmen Loquai13,
  16. Peter Mohr14,
  17. Ralf Gutzmer15,
  18. Reinhard Dummer7,
  19. Stacey Gabriel2,
  20. Catherine J. Wu1,2,
  21. Dirk Schadendorf4,5,,
  22. Levi A. Garraway1,2,3,
  1. 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  2. 2Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  3. 3Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  4. 4Department of Dermatology, University Hospital, University Duisburg—Essen, 45147 Essen, Germany.
  5. 5German Cancer Consortium(DKTK), 69121 Heidelberg, Germany.
  6. 6Department of Medical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
  7. 7Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
  8. 8Skin Cancer Unit, German Cancer Research Center(DKTK), 69121 Heidelberg, Germany.
  9. 9Department of Dermatology, Venerology, and Allergology, University Medical Center, Ruprecht-Karls University of Heidelberg, 68167 Mannheim, Germany.
  10. 10Department of Dermatology, University Hospital, Ruprecht-Karls University of Heidelberg, 69120 Heidelberg, Germany.
  11. 11Department of Dermatology, University Hospital Tübingen, 72076 Tübingen, Germany.
  12. 12Department of Dermatology, University Hospital Kiel, 24105 Kiel, Germany.
  13. 13Department of Dermatology, University Medical Center, 55131 Mainz, Germany.
  14. 14Department of Dermatology, Elbe-Kliniken, 21614 Buxtehude, Germany.
  15. 15Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, 30625 Hannover, Germany.
  1. Corresponding author. E-mail: levi_garraway{at}dfci.harvard.edu (L.A.G.); dirk.schadendorf{at}uk-essen.de (D.S.)
  1. * These authors contributed equally to this work.

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