Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

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Science  09 Oct 2015:
Vol. 350, Issue 6257, pp. 217-221
DOI: 10.1126/science.aab3369

Orchestrating a viral takeover

For some pathogenic viruses, outbreaks occur when a new viral strain emerges and displaces the endemic strain. How such a takeover occurs at a molecular level, however, remains an open question. Manokaran et al. examined one example, the emergence of a new clade of dengue virus (DENV) that caused an outbreak in Puerto Rico in 1994. The epidemic strain produced elevated amounts of subgenomic flavivirus RNA (sfRNA), a viral noncoding RNA, relative to amounts of genomic viral RNA. sfRNA bound to and inhibited TRIM25, a protein important for activating the host's antiviral response, and so by reducing host immunity was able to increase its own fitness.

Science, this issue p. 217