Cell Aging

Yeast reveal the secrets for a long life

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Science  30 Oct 2015:
Vol. 350, Issue 6260, pp. 525-526
DOI: 10.1126/science.350.6260.525-f

For scientists, the genetic basis of aging largely remains a mystery. McCormick et al. sought to shed light on this mystery by conducting a 10-year study of the replicative life span (that is, the number of daughter cells that a given cell produces) in 4698 strains of yeast, each of which had a different gene deleted. The authors detected 238 genes that promoted longevity when deleted. They then grouped them into functional categories, the largest being genes that encode components of the ribosome, a large molecular machine that drives protein synthesis. Many genes associated with yeast longevity overlapped with those that regulate this process in Caenorhabditis elegans.

Cell Metab. 10.1016/j.cmet.2015.09.008 (2015).

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