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Pharmacological chaperone for α-crystallin partially restores transparency in cataract models

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Science  06 Nov 2015:
Vol. 350, Issue 6261, pp. 674-677
DOI: 10.1126/science.aac9145

Article Information

vol. 350 no. 6261 674-677

PubMed: 
Print ISSN: 
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History: 
  • Received for publication June 27, 2015
  • Accepted for publication September 21, 2015
  • .

Author Information

  1. Leah N. Makley1,*,
  2. Kathryn A. McMenimen1,*,
  3. Brian T. DeVree3,
  4. Joshua W. Goldman2,
  5. Brittney N. McGlasson2,
  6. Ponni Rajagopal4,
  7. Bryan M. Dunyak1,
  8. Thomas J. McQuade5,
  9. Andrea D. Thompson1,
  10. Roger Sunahara3,
  11. Rachel E. Klevit4,
  12. Usha P. Andley2,,
  13. Jason E. Gestwicki1,5,
  1. 1Departments of Pathology, Biological Chemistry, and Medicinal Chemistry and the Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
  2. 2Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.
  3. 3Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.
  4. 4Department of Biochemistry, University of Washington, Seattle, WA, USA.
  5. 5Center for Chemical Genomics, University of Michigan, Ann Arbor, MI, USA.
  1. Corresponding author. E-mail: jason.gestwicki{at}ucsf.edu (J.E.G.);
    andley{at}vision.wustl.edu (U.P.A.)
  1. * These authors contributed equally to this work.

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