In DepthMedicine

Cancer research centers pool tumor genome data

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Science  13 Nov 2015:
Vol. 350, Issue 6262, pp. 730
DOI: 10.1126/science.350.6262.730

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An international consortium of academic research centers is pooling data on patients' tumor genomes and their clinical outcomes to learn more about the role of cancer-causing mutations. The American Association for Cancer Research's Project GENIE, which stands for Genomics, Evidence, Neoplasia, Information, Exchange, so far includes seven institutions in the United States, Canada, and Europe. These centers are analyzing tumors for mutations in hundreds of cancer genes. GENIE will allow the centers to share data through a central repository to learn how these mutations influence a patient's prognosis and response to drugs. So far, the registry has data on 17,000 patients and hopes to reach 100,000 within 5 years.