In DepthCANCER IMMUNOTHERAPY

Baby's leukemia recedes after novel cell therapy

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Science  13 Nov 2015:
Vol. 350, Issue 6262, pp. 731
DOI: 10.1126/science.350.6262.731

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  • Why leukemia strikes the young?
    • Qiuyun Liu, Professor, Guangdong Provincial Key Laboratory of Improved Variety Reproduction in Aquatic Economic Animals, Sun Yat-sen University
    • Other Contributors:
      • Fan Feng, Student, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
      • Zijin Li, Student, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
      • Zhenlang Chen, Student, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China

    Collagens, distributed around joints and in other parts of the body, possess about 20% proline and hydroxyproline (GenBank accession number AAB59373.1 and AAI16450.1). The hydrogen bonding capacity of these and other amino acid residues may underlie certain human diseases. The proximity of collagens in connective tissues to bone marrow cells may be carcinogenic to sensitive people as local buildup of HCl is mutagenic (1-3). Hemoglobin is a major constituent of erythrocytes and harbors 15.6% basic amino acids (GenBank accession number NP_000509.1) which attract anions such as chloride ions. Hemoglobin in erythrocytes can spread to nearby cells. Myoglobin could also have minor effect on leukemia risks as red meat is characterized by the presence of myoglobin with about 21% basic amino acids (GenBank accession number NP_776306.1). Red meat is somewhat carcinogenic, as WHO announced before. The major risk factors for leukemia are present at all ages, unlike some other cancers with incidences peaking at old age, when proton buildup is triggered by attenuated respiratory chain and normal Krebs cycle. The aforementioned scenario accounts for the high incidences of juvenile leukemia.

    Fan Feng, 1,2 Zijin Li, 1,2 Zhenlang Chen, 1,2 Qiuyun Liu 1,*
    1. Guangdong Provincial Key Laboratory of Improved Variety Reproduction in Aquatic Economic Animals, State Key Laboratory of Biocontrol, Biotechnology Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou...

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    Competing Interests: None declared.