Erratum for the Report “Genomic correlates of response to CTLA-4 blockade in metastatic melanoma” by E. M. Van Allen, D. Miao, B. Schilling, S. A. Shukla, C. Blank, L. Zimmer, A. Sucker, U. Hillen, M. H. Geukes Foppen, S. M. Goldinger, J. Utikal, J. C. Hassel, B. Weide, K. C. Kaehler, C. Loquai, P. Mohr, R. Gutzmer, R. Dummer, S. Gabriel, C. J. Wu, D. Schadendorf, L. A. Garraway

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Science  13 Nov 2015:
Vol. 350, Issue 6262, aad8366
DOI: 10.1126/science.aad8366

In the Report “Genomic correlates of response to CTLA-4 blockade in metastatic melanoma,” two summary values were incorrect. Since publication, an independent group of investigators noticed a small number of missing data entries in table S4 concerning neoantigen binding affinities in one patient (Pat110 in the Report). The authors traced this issue and discovered a subtle error in the neoantigen calling pipeline for this single patient, which led to inappropriate deletion of a few neoantigens. Correcting the neoantigen calls in this case does not alter the results or conclusions of this investigation. The source of the error pertained to extremely high mutational burden in this case (the highest observed in this sample collection). The authors repeated all analyses and confirmed that this issue does not affect neoantigen calling in any of the other samples. The two summary values in the main text have been updated; no changes have been made to the main figures or tables. Figure S1 and tables S2, S3, and S4 in the supplementary materials have been updated to reflect this change.

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