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Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

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Science  27 Nov 2015:
Vol. 350, Issue 6264, pp. 1079-1084
DOI: 10.1126/science.aad1329

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vol. 350 no. 6264 1079-1084

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History: 
  • Received for publication July 31, 2015
  • Accepted for publication October 21, 2015
  • .

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Author Information

  1. Marie Vétizou1,2,3,
  2. Jonathan M. Pitt1,2,3,
  3. Romain Daillère1,2,3,
  4. Patricia Lepage4,
  5. Nadine Waldschmitt5,
  6. Caroline Flament1,2,6,
  7. Sylvie Rusakiewicz1,2,6,
  8. Bertrand Routy1,2,3,6,
  9. Maria P. Roberti1,2,6,
  10. Connie P. M. Duong1,2,6,
  11. Vichnou Poirier-Colame1,2,6,
  12. Antoine Roux1,2,7,
  13. Sonia Becharef1,2,6,
  14. Silvia Formenti8,
  15. Encouse Golden8,
  16. Sascha Cording9,
  17. Gerard Eberl9,
  18. Andreas Schlitzer10,
  19. Florent Ginhoux10,
  20. Sridhar Mani11,
  21. Takahiro Yamazaki1,2,6,
  22. Nicolas Jacquelot1,2,3,
  23. David P. Enot1,7,12,
  24. Marion Bérard13,
  25. Jérôme Nigou14,15,
  26. Paule Opolon1,
  27. Alexander Eggermont1,2,16,
  28. Paul-Louis Woerther17,
  29. Elisabeth Chachaty17,
  30. Nathalie Chaput1,18,
  31. Caroline Robert1,16,19,
  32. Christina Mateus1,16,
  33. Guido Kroemer7,12,20,21,22,
  34. Didier Raoult23,
  35. Ivo Gomperts Boneca24,25,*,
  36. Franck Carbonnel3,26,*,
  37. Mathias Chamaillard5,*,
  38. Laurence Zitvogel1,2,3,6,
  1. 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.
  2. 2INSERM U1015, GRCC, Villejuif, France.
  3. 3University of Paris Sud XI, Kremlin-Bicêtre, France.
  4. 4Institut National de la Recherche Agronomique (INRA), Micalis-UMR1319, 78360 Jouy-en-Josas, France.
  5. 5University of Lille, CNRS, INSERM, Centre Hospitalier Régional Universitaire de Lille, Institut Pasteur de Lille, U1019, UMR 8204, Centre d'Infection et d'Immunité de Lille (CIIL), F-59000 Lille, France.
  6. 6Center of Clinical Investigations in Biotherapies of Cancer 1428, Villejuif, France.
  7. 7Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
  8. 8Department of Radiation Oncology, New York University, New York, NY, USA.
  9. 9Microenvironment and Immunity Unit, Institut Pasteur, Paris, France.
  10. 10Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
  11. 11Department of Genetics and Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  12. 12Metabolomics Platform, GRCC, Villejuif, France.
  13. 13Animalerie Centrale, Institut Pasteur, Paris, France.
  14. 14Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France.
  15. 15Université de Toulouse, Université Paul Sabatier, IPBS, F-31077 Toulouse, France.
  16. 16Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France.
  17. 17Service de microbiologie, GRCC, Villejuif, France.
  18. 18Laboratory of Immunomonitoring in Oncology, UMS 3655 CNRS/US 23 INSERM, GRCC, Villejuif, France.
  19. 19INSERM U981, GRCC, Villejuif, France.
  20. 20INSERM U848, Villejuif, France.
  21. 21Equipe 11 Labellisée—Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, INSERM U1138, Paris, France.
  22. 22Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique—Hôpitaux de Paris, Paris, France.
  23. 23Unité des Rickettsies, Faculté de Médecine, Université de la Méditerranée, Marseille, France.
  24. 24Institut Pasteur, Unit of Biology and Genetics of the Bacterial Cell Wall, Paris, France.
  25. 25INSERM, Equipe Avenir, Paris, France.
  26. 26Gastroenterology Department, Hôpital Bicêtre, Assistance Publique—Hôpitaux de Paris, Paris, France.
  1. Corresponding author. E-mail: laurence.zitvogel{at}gustaveroussy.fr
  1. * These authors contributed equally to this work.

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